For mechanically ventilated spaces, run ventilation calculations to verify that the final design meets the minimum outside air rates equal to or exceeding the ASHRAE 62.1-2007 minimum.
Continue to run calculations and develop flow diagrams to inform the design process and confirm compliance. If you are using a natural ventilation modeler for the project, use the model as a tool to inform design development.
The mechanical engineer continues to run ventilation rate calculations during the mechanical design process to inform design development and confirm compliance with this prerequisite. The ventilation rate procedure is explained in section 6 of ASHRAE 62.1-2007. See the attached 62MZ calculator.
Consider using Computational Fluid Dynamics (CFD) modeling to determine proper opening sizes and ensure proper airflow. Some energy modeling programs also have CFD analysis capabilities.