Can anyone advise how I should go about running the energy model for a building whose supply air & outside air quantities are being driven not by actual load, but by Unified facilities Criteria (UFC)?

Should my proposed building airflow & subsequent energy use be reflective of the minimum REQUIRED airflows per ASHRAE and our proposed building envelope... or by the minimum ACH rates dictated by UFC?

How do I compare "apples to apples" with the baseline rotations that are governed by ASHRAE?

Thank you for any help that can be given... there is a DRASTIC difference in energy usage with these two methods.