Applicablility of Options for BD+C Rating System

I noticed that three options are available for the energy performance credit: 1) whole-building energy simulation, 2) Prescriptive compliance: ASHRAE 50% Advanced Energy Design Guide, and 3) Prescriptive compliance: Advanced BuildingsTM Core PerformanceTM Guide. The building that I am looking to get LEED certified is a fish scrap fertilizer plant so I was wondering, since option 2 only provides the ASHRAE 50% Design Guide for Small to Medium Office Buildings, for office buildings smaller than 100,000 square feet (9 290 square meters), large hospitals, schools, and retail buildings, would option 2 be an applicable option in the case of the fertilizer plant (which is more of a manufacturing environment)?