Showing energy savings in drug manufacturing facilities

Has anyone performed an exceptional alculation to demonstrate energy savings in a drug manufacturing facility for EAc1? We are trying to demonstrate an improvement and savings by lowering the required classification of spaces.. I.E. changing from a Grade A space at 90 fpm requirements to Grade B, C, or D. This can reduce the air change rates drastically. This of course reduces building loads and energy consumption drastically, shrinks the HVAC equipment, and may even reduce the overall building footprint that is required. Has anyone successfully done this for LEED? Maybe this also falls under the Innovative Category, for shrinking the building footprint? If anyone has any advice to offer, that would be great; example project, resource, website, etc.. This may fall under the realm of process load reduction.